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HRID 237284作成日：2026年10月25日
Cyanomethylenetributylphosphorane → 1-Benzhydryl-3-[5-bromo-2-(3-chloro-benzyloxy)-phenoxy]-3-methyl-azetidine
https://huagongshe.com/reaction/237284
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 反応物 | 1-Benzhydryl-3-methylazetidin-3-ol | HCID 10243989 | — |
| 反応物 | 5-Bromo-2-(3-chloro-benzyloxy)-phenol | HCID 67347295 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzhydryl-3-[5-bromo-2-(3-chloro-benzyloxy)-phenoxy]-3-methyl-azetidine | HCID 67348353 | 43.7% |
反応手順
The mixture of the title compound from Step A (0.5 mmol), 5-bromo-2-(3-chloro-benzyloxy)-phenol (0.5 mmol), and cyanomethylenetri-n-butylphosphorane (0.5 mmol) in toluene (3 mL) was heated at 150° C. in a microwave reactor for 1 h. The mixture was cooled to rt and purified via PTLC providing the title compound (120 mg). MS (ESI): mass calcd. for C30H27BrClNO2, 547.1; m/z found, 548.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08642583B2 |
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| 出典データセット | uspto-grants-2014_02 |
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| ORD ID | ord-2459de9a057140f6bdde4ce0d97113d0 |
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| 出典メモ | uspto-grants-2014_02 |
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