Sodium Methoxide → 2-cyanophenyl 5-thio-beta-D-xylopyranoside

HRID 2373006ノート

反応式

HRID 2373006 の反応式
C([O:4][C@@H:5]1[C@@H:19]([O:20]C(=O)C)[C@H:18]([O:24]C(=O)C)[CH2:17][S:16][C@H:6]1[O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]#[N:15])(=O)C.C[O-].[Na+]>CO>[O:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]#[N:15])[C@@H:6]1[S:16][CH2:17][C@@H:18]([OH:24])[C@H:19]([OH:20])[C@H:5]1[OH:4]

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 150678542-cyanophenyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside

生成物 1

HCID 150678552-cyanophenyl 5-thio-beta-D-xylopyranoside収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

If the procedure described in Preparation LXXXIV is followed starting from 1.26 g (3.2.10-3 mol) of 2-cyanophenyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside and 0.2 ml of a solution of sodium methylate in methanol (8% w/v of Na), reacted in 70 ml of methanol for 30 min, 0.75 g (yield: 88%) of the expected product is obtained after precipitation in ether and lyophilization.

後処理

  1. customIf the procedure described in Preparation LXXXIV

出典と根拠

ORDレコード
ord-e5ad4023439a4433a929735d9307d2cb
出典データセット
uspto-grants-1992_03
特許番号
US05101048

反応ノート

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