Water → (E)-1,4-Bis(-4-bromostyryl)benzene

関与物質

役割	名称	HCID	仕込み量
反応物	Water	HCID 962	—
反応物	Sodium Hydroxide	HCID 14798	—
反応物	4-Bromobenzaldehyde	HCID 70741	—
反応物	Phosphonic acid, P,P'-(1,4-phenylenebis(methylene))bis-, P,P,P',P'-tetraethyl ester	HCID 78303	—
触媒	Tetrabutylammonium Iodide	HCID 67553	—
溶媒	Benzene	HCID 241	—
生成物	(E)-1,4-Bis(-4-bromostyryl)benzene	HCID 12266563	—

反応手順

50% aqueous sodium hydroxide (20 ml) was added to a solution of tetraethyl p-xylylenebisphosphonate (2.40 g, 6.35 mmol) (25) and 4-bromobenzaldehyde (2.41 g, 13.02 mmol) in 10 ml of benzene. Tetra-n-butylammonium iodide (148 mmg) was added and the mixture was refluxed under nitrogen for 1 hour. The reaction mixture was allowed to cool and diluted by the addition of water (25 ml). A yellow solid was collected and washed three times with water, methanol and ether. The product was purified by recrystallization from xylenes and was isolated in 61.9% (1.73 g) yield (Product is insoluble in standard solvents).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07459106B2
出典データセット	uspto-grants-2008_12
ORD ID	ord-c9179945d71441d98244d7e77c38dd4d
出典メモ	uspto-grants-2008_12