Hydrochloric Acid → (R)-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one hydrochloride

反応式

[OH:1][C@@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][C:9]2[NH:10][C:11](=[O:20])[C:12]3[C:17]([CH:18]=2)=[C:16]([CH3:19])[CH:15]=[CH:14][CH:13]=3)[CH2:3]1.[ClH:21]>>[ClH:21].[OH:1][C@@H:2]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][C:9]2[NH:10][C:11](=[O:20])[C:12]3[C:17]([CH:18]=2)=[C:16]([CH3:19])[CH:15]=[CH:14][CH:13]=3)[CH2:3]1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 10378544(R)-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one

生成物 1

HCID 68644147(R)-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one hydrochloride

実験手順

Using a known method, (R)-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one was converted to a hydrochloride to give (R)-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one hydrochloride.

出典と根拠

ORDレコード: ord-e76e3a73302b450e9c1c266deb852e3a
出典データセット: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07459465B2

反応ノート

読み込み中…