Acetic Anhydride → N-(5-iodo-2-methylphenyl)acetamide

HRID 2373349ノート

反応式

HRID 2373349 の反応式
[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([NH2:8])[CH:7]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[I:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([NH:8][C:10](=[O:12])[CH3:11])[CH:7]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 5228025-Iodo-o-toluidine

生成物 1

HCID 14233595N-(5-iodo-2-methylphenyl)acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
50 °C

実験手順

A solution of 5-iodo-2-methyl-phenylamine (20.4 g, 87.6 mmol) in 200 mL of dry CH2Cl2 was cooled to 0° C. and acetic anhydride (16.5 mL, 175 mmol) was added dropwise. The mixture was heated to 50° C. for 2 h and then cooled to 22° C. The resulting white precipitate was filtered to give c (18.4 g, 76%): MS m/z═276 (M+H).

後処理

  1. temperaturecooled to 22° C
  2. filtrationThe resulting white precipitate was filtered
  3. customto give c (18.4 g, 76%)

出典と根拠

ORDレコード
ord-4931c974a94a4a97a4c5ef6253db6017
出典データセット
uspto-grants-2008_12
特許番号
US07459448B2

反応ノート

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