Hydrochloric Acid → Methyl 2-amino-5-methoxybenzoate

HRID 2373351

反応式

HRID 2373351 の反応式
Cl.[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:14]O>>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:14])=[O:6]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2779305-Methoxyanthranilic acid

生成物 1

HCID 13052275Methyl 2-amino-5-methoxybenzoate

反応条件

温度
60 °C

実験手順

Hydrogen chloride gas was bubbled through a solution of 2-amino-5-methoxybenzoic acid (5.0 g, 30 mmol) in MeOH (200 mL) for 30 minutes. The solution was heated at 60° C. overnight. The reaction was cooled and the solvent removed in vacuo. The residue was dissolved in water, basified with 5M NaOH and extracted twice with ether. The ether extracts were washed with 5M NaOH and water, dried (MgSO4), filtered and concentrated in vacuo to give i-e (4.25 g, 78%): MS m/z═182 (M+H).

後処理

  1. temperatureThe reaction was cooled
  2. customthe solvent removed in vacuo
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted twice with ether
  5. washThe ether extracts were washed with 5M NaOH and water
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customto give i-e (4.25 g, 78%)

出典と根拠

ORDレコード
ord-485b0003c27d4732bd3d76857f9246f2
出典データセット
uspto-grants-2008_12
特許番号
US07459448B2

関連ノート

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