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Benzyl isocyanate → (4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino} sulfonyl)amino]methyl}cyclohexyl)methyl 3-methoxyphenylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl isocyanate | HCID 76639 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Methoxyphenyl isocyanate | HCID 87843 | — |
| 反応物 | (4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino}sulfonyl)amino]methyl}cyclohexyl)methyl benzylcarbamate | HCID 22574464 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | (4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino} sulfonyl)amino]methyl}cyclohexyl)methyl 3-methoxyphenylcarbamate | HCID 22574485 | — |
反応手順
Following procedure to make (9), 3-methoxyphenyl isocyanate was substituted for benzyl isocyanate and diisopropylethylamine substituted for triethylamine to give the title compound after purification. 1H NMR (500 MHz, DMSO-d6): δ 9.50 (s, 1H), 8.45 (s, 2H), 8.10 (s, 1H), 7.38 (d, 2H), 7.24 (t, 2H), 7.14 (m, 3H), 6.96 (d, 1H), 6.52 (d, 1H), 4.35 (s, 2H), 3.75 (d, 2H), 3.68 (s, 3H), 3.30 (water), 2.89 (d, 2H), 2.48 (DMSO), 1.63 (m, 4H), 1.42 (m, 1H), 1.29 (m, 1H), 0.66 (m, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06852738B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-3754d13e72ce47f49728e435d6baaf46 |
| 出典メモ | uspto-grants-2005_02 |