3-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-benzoic Acid Ethyl Ester → 4-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-N,N-dimethyl-benzamide
反応式
C(OC(=O)C1C=CC=C(C#C[C:13]2[CH:25]=[CH:24][C:16]3[O:17][CH2:18][C:19]([CH3:23])([CH3:22])[CH2:20][O:21][C:15]=3[CH:14]=2)C=1)C.[C:27]([C:29]1[CH:39]=[CH:38][C:32]([C:33]([N:35]([CH3:37])[CH3:36])=[O:34])=[CH:31][CH:30]=1)#[CH:28].IC1C=CC2OCC(C)(C)COC=2C=1>>[CH3:22][C:19]1([CH3:23])[CH2:18][O:17][C:16]2[CH:24]=[CH:25][C:13]([C:28]#[C:27][C:29]3[CH:39]=[CH:38][C:32]([C:33]([N:35]([CH3:37])[CH3:36])=[O:34])=[CH:31][CH:30]=3)=[CH:14][C:15]=2[O:21][CH2:20]1参加物
4
反応物 3
生成物 1
実験手順
The title compound is prepared in analogy to 3-(3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-benzoic acid ethyl ester (10) from 4-ethynyl-N,N-dimethyl-benzamide and 7-iodo-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine (5) as a light brown solid, MS (ESI) 699.4 (100, [2M+H]+), 350.4 (15, [M+H]+).