Hexahydro-2-benzimidazolinone → 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)octahydro-2H-benzimidazol-2-one
反応式
I[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]4)[CH2:12][CH2:11]2)[CH:5]=[CH:6][CH:7]=1.[NH:27]1[CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]2[NH:29][C:28]1=[O:36]>>[CH3:26][C:20]1[CH:19]=[CH:18][C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[N:13]2[CH2:14][CH2:15][N:10]([CH2:9][CH2:8][C:4]3[CH:3]=[C:2]([N:27]4[CH:31]5[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]5[NH:29][C:28]4=[O:36])[CH:7]=[CH:6][CH:5]=3)[CH2:11][CH2:12]2)[N:21]=1参加物
3
実験手順
The title compound was prepared in 100% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 5-{4-[2-(3-iodophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and octahydro-2H-benzimidazol-2-one.
出典と根拠
- ORDレコード
- ord-b98c789e91fe49099a16654567e66658
- 出典データセット
- uspto-grants-2008_12