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3-Bromo-5-chloro-2,6-dimethoxybenzoic acid → 3-Biphenyl-4-yl-2-(S)-(3-bromo-5-chloro-2,6-dimethoxy-benzoylamino)-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromo-5-chloro-2,6-dimethoxybenzoic acid | HCID 2800463 | — |
| 反応物 | (S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-aminopropanoate | HCID 15714801 | — |
| 生成物 | 3-Biphenyl-4-yl-2-(S)-(3-bromo-5-chloro-2,6-dimethoxy-benzoylamino)-propionic acid | HCID 11214537 | 80.6% |
反応手順
2-(S)-amino-3-biphenyl-4-yl-propionic acid methyl ester (128 mg, 0.5 mmol) was reacted with 3-bromo-5-chloro-2,6-dimethoxybenzoic acid (148 mg, 0.5 mmol) as described in general procedure A. The resulting compound was hydrolyzed according to general procedure C to afford the title product (209 mg) as a pure white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07459472B2 |
| 出典データセット | uspto-grants-2008_12 |
| ORD ID | ord-89c162e8b9094729a4a59f739fd14519 |
| 出典メモ | uspto-grants-2008_12 |