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Benzoyl Peroxide → Methyl 5-(bromomethyl)pyrazine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 2-Pyrazinecarboxylic acid, 5-methyl-, methyl ester | HCID 465065 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | Methyl 5-(bromomethyl)pyrazine-2-carboxylate | HCID 21973569 | 29.6% |
反応手順
To a solution of 5-methyl-pyrazine-2-carboxylic acid methyl ester (2.0 g, 13.146 mmol) in CCl4 (25 mL0 was added NBS (2.57 g, 14.461 mmol) and benzoyl peroxide (0.318 g, 1.314 mmol) and the solution was heated at 70 C. for 1 h. Upon cooling to RT, the organic layer was washed with NaHCO3, water, dried (Na2SO4), and concentrated under reduced pressure to give 0.900 g 5-Bromomethyl-pyrazine-2-carboxylic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07459472B2 |
| 出典データセット | uspto-grants-2008_12 |
| ORD ID | ord-943813d9e5094dcda8d8d0ea79ce405a |
| 出典メモ | uspto-grants-2008_12 |