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Potassium Carbonate → 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-(Trifluoromethoxy)phenol | HCID 2733261 | — |
| 反応物 | Methyl 5-(bromomethyl)pyrazine-2-carboxylate | HCID 21973569 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester | HCID 69206346 | 88.1% |
反応手順
A solution of 5-bromomethyl-pyrazine-2-carboxylic acid methyl ester (0.305 g, 1.314 mmol) in DMF (6 mL) was treated with 3-trifluoromethoxyphenol (0.280 g, 1.577 mmol) and potassium carbonate (0.400 g, 2.89 mmol) by the general procedure G. The crude product was purified by flash column chromatography on silica gel to give 0.380 g of pure 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester. LCMS: 330 (M+2)+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07459472B2 |
| 出典データセット | uspto-grants-2008_12 |
| ORD ID | ord-b547a5d1b0354d98b065c0720cf92894 |
| 出典メモ | uspto-grants-2008_12 |