ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Ethyl Acetate → C-[2-Amino-6-(2,4-dimethylphenyl)-5-formyl-pyrimidin-4-ylsulphanyl]-N-cyclopropyl-methane sulphonamide

HRID 237390
ノート
印刷プレビュー

反応式

HRID 237390 の反応式
C(=O)([O-])O.[Na+].[NH2:6][C:7]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[CH3:20])[C:10]([CH:21]=[O:22])=[C:9]([SH:23])[N:8]=1.Br[CH2:25][S:26]([NH:29][CH:30]1[CH2:32][CH2:31]1)(=[O:28])=[O:27].C(OCC)(=O)C>CN(C=O)C>[NH2:6][C:7]1[N:8]=[C:9]([S:23][CH2:25][S:26]([NH:29][CH:30]2[CH2:32][CH2:31]2)(=[O:28])=[O:27])[C:10]([CH:21]=[O:22])=[C:11]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[CH3:20])[N:12]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 516892Sodium BicarbonateHCID 68594886C-bromo-N-cyclopropyl-methane sulphonamideHCID 178423997HCID 178423997、化合物

生成物 1

HCID 59519319C-[2-Amino-6-(2,4-dimethylphenyl)-5-formyl-pyrimidin-4-ylsulphanyl]-N-cyclopropyl-methane sulphonamide

試薬・触媒・溶媒 1

HCID 6228
Dimethylformamide
溶媒

反応条件

温度
85 °C

実験手順

Sodium hydrogen carbonate was added to a solution of 2-Amino-4-(2,4-dimethylphenyl)-6-mercapto-pyrimidine-5-carbaldehyde in DMF and the suspension stirred. C-bromo-N-cyclopropyl-methane sulphonamide was added, and the mixture heated, ˜85° C., for ˜3 hrs. The resulting suspension was allowed to cool and ethyl acetate added, the mixture was washed with water and saturated aqueous sodium chloride solution. The solution was dried over anhydrous sodium sulphate and concentrated to a pale yellow solid. The crude solid was purified by column chromatography on silica eluting with mixtures of ethyl acetate and hexane.

後処理

  1. temperatureto cool
  2. washthe mixture was washed with water and saturated aqueous sodium chloride solution
  3. dry with materialThe solution was dried over anhydrous sodium sulphate
  4. concentrationconcentrated to a pale yellow solid
  5. customThe crude solid was purified by column chromatography on silica eluting with mixtures of ethyl acetate and hexane

出典と根拠

ORDレコード
ord-6f2c1cc392754620be8079bc2fba08df
出典データセット
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08642594B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート