2-Bromopyridine → 1-(Pyridin-2-yl)-1H-pyrazole-4-carbaldehyde

HRID 2374142ノート

反応式

HRID 2374142 の反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH:12]=[CH:11][C:10](C=O)=[N:9]1.[C:15](=O)([O-])[O-:16].[K+].[K+]>CN(C=O)C.O>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:9]1[CH:10]=[C:11]([CH:15]=[O:16])[CH:12]=[N:8]1

参加物

6

反応物 3

HCID 79732-BromopyridineHCID 11430Potassium CarbonateHCID 122183831H-pyrazole-3-carbaldehyde

生成物 1

HCID 247048931-(Pyridin-2-yl)-1H-pyrazole-4-carbaldehyde

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

A mixture of 2-bromopyridine (3.4 mmol), 3-pyrazolecarboxaldehyde (3.2 mmol), and potassium carbonate (3.4 mmol) in anhydrous DMF (6 mL) was heated to 120° C. for 24 h. The reaction was cooled to RT, diluted with water, and extracted with EtOAc (3 x). The organic layers were combined and dried (Na2SO4), filtered, and concentrated. The title compound was obtained upon purification (SGC using EtOAc:hexanes gradient eluant from 0% to 100% EtOAc).

後処理

  1. temperatureThe reaction was cooled to RT
  2. extractionextracted with EtOAc (3 x)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-ddf04c95c67f4704841a0f5dbde79a7b
出典データセット
uspto-grants-2008_12
特許番号
US07462600B2

反応ノート

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