Water → HCID 63812334、化合物
反応式
F[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:13]1[CH:17]=[N:16][CH:15]=[N:14]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5])([O-:12])=[O:11]参加物
6
反応条件
- 温度
- 50 °C
実験手順
2-Fluoro-5-nitro-benzonitrile (1.0 g, 6.0 mmol) was dissolved in anhydrous DMF (6 mL), then treated with [1,2,4]-triazole (0.46 g, 6.7 mmol), cesium carbonate (2.9 g, 8.9 mmol), and heated (50° C.) overnight. After cooling to RT, the mixture was treated with water and the solid title compound collected by filtration (1.14 g). MS (ESI+) for m/z 216 (M+H)+.
後処理
- temperatureAfter cooling to RT
- filtrationthe solid title compound collected by filtration (1.14 g)
出典と根拠
- ORDレコード
- ord-c462e9405f1b4f0ab408b1267dd0a4bd
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07462600B2
反応ノート
読み込み中…