4-(methylsulfonyl)-Biphenyl-2-carboxylic acid → [4-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazin-1-yl]-(4-methanesulfonyl-biphenyl-2-yl)-methanone

HRID 2374270

反応式

HRID 2374270 の反応式
[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[C:9]([F:19])[CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1.[CH3:20][S:21]([C:24]1[CH:25]=[C:26]([C:36](O)=[O:37])[C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:28][CH:29]=1)(=[O:23])=[O:22]>>[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:14][CH2:15][N:16]([C:36]([C:26]4[CH:25]=[C:24]([S:21]([CH3:20])(=[O:23])=[O:22])[CH:29]=[CH:28][C:27]=4[C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[O:37])[CH2:17][CH2:18]3)=[C:9]([F:19])[CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 574452544-(methylsulfonyl)-Biphenyl-2-carboxylic acidHCID 598536651-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine

生成物 1

HCID 59853643[4-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazin-1-yl]-(4-methanesulfonyl-biphenyl-2-yl)-methanone

実験手順

The title compound was prepared according to the procedure E described for Example 9 from 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine (Example W) and 4-Methanesulfonyl-biphenyl-2-carboxylic acid (Example V). MS (ISP): 543.3 MH+.

出典と根拠

ORDレコード
ord-ff42736d68894285b75523a5380741a5
出典データセット
uspto-grants-2008_12
特許番号
US07462617B2

関連ノート

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