Sodium Hydroxide → Sodium 4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylate

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Hydroxide	HCID 14798	—
反応物	4-{4-[4-(3-Methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester	HCID 58017093	—
溶媒	Water	HCID 962	—
溶媒	Isopropanol	HCID 3776	—
生成物	Sodium 4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylate	HCID 86659980	96.9%

反応条件

温度	82 °C

反応手順

A 50% (w/w) aqueous solution of NaOH in H2O (198.95 g) was added to 4-{4-[4-(3-Methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid methyl ester (830.0 g) in IPA (7.5 L) and the mixture allowed to stir at 82° C. for 1 h and then stirred overnight at room temperature. The mixture was then filtered, and the solid rinsed with IPA, and dried in vacuo at 60° C. for 3 days to yield sodium 4-{4-[4-(3-methanesulfonyl-propoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylate (96.9%).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08642601B2
出典データセット	uspto-grants-2014_02
ORD ID	ord-b35a96e046774f5597471ec4b2a42eb0
出典メモ	uspto-grants-2014_02