Isopropanol → 7-Fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one

反応式

F[C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:13])[NH:5][CH:6]=[N:7]2.[CH:14]([OH:17])([CH3:16])[CH3:15]>>[F:12][C:10]1[CH:9]=[C:8]2[C:3]([C:4](=[O:13])[NH:5][CH:6]=[N:7]2)=[C:2]([O:17][CH:14]([CH3:16])[CH3:15])[CH:11]=1

参加物

反応物 2

HCID 3776Isopropanol

HCID 1355106875,7-Difluoro-3,4-dihydroquinazolin-4-one

生成物 1

HCID 1362314007-Fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one収率 73%

実験手順

5,7-Difluoro-3,4-dihydroquinazolin-4-one was reacted with isopropanol to give 7-fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one in 73% yield; NMR Spectrum: (DMSOd6) 1.31 (s, 6H), 4.73 (m, 1H), 6.89 (m, 1H), 6.95 (m, 1H), 7.96 (s, 1H); Mass Spectrum: M+H+ 223.

出典と根拠

ORDレコード: ord-f777f8ded35d4767b570927d1bae6996
出典データセット: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07462623B2

反応ノート

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