3-(1-Acetylpiperidin-4-yl)propanoic acid → 9-[3-(1-Acetyl-4-piperidinyl)propanoyl]-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one

HRID 2374604

反応式

HRID 2374604 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH2:15]1[C:24]2[C:19]3=[C:20]([CH2:25][CH2:26][C:27](=[O:28])[N:18]3[CH2:17][CH2:16]1)[CH:21]=[CH:22][CH:23]=2>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([CH2:10][CH2:11][C:12]([C:22]2[CH:23]=[C:24]3[C:19]4=[C:20]([CH2:25][CH2:26][C:27](=[O:28])[N:18]4[CH2:17][CH2:16][CH2:15]3)[CH:21]=2)=[O:14])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 98557513-(1-Acetylpiperidin-4-yl)propanoic acidHCID 136945641,2,6,7-tetrahydro-5H-pyrido[3,2,1-ij]quinolin-3-one

生成物 1

HCID 218877659-[3-(1-Acetyl-4-piperidinyl)propanoyl]-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one

実験手順

Using 3-(1-acetyl-4-piperidinyl)propanoic acid (13.8 g) and 2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-5-one (10.8 g) according to the same method as that of Reference Example 172, the title compound was obtained as colorless crystals (15.5 g) having a melting point of 130 to 131° C.

出典と根拠

ORDレコード
ord-e08fc3af4ab449f2a6798eb5b3edee5d
出典データセット
uspto-grants-2008_12
特許番号
US07462628B2

関連ノート

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