1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → 5-(4-Bromo-3,5-dimethylphenyl)-1-methyl-1H-pyrazole
反応式
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](I)=[CH:4][C:3]=1[CH3:10].[CH3:11][N:12]1[C:16](B2OC(C)(C)C(C)(C)O2)=[CH:15][CH:14]=[N:13]1>>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([C:16]2[N:12]([CH3:11])[N:13]=[CH:14][CH:15]=2)=[CH:4][C:3]=1[CH3:10]参加物
3
実験手順
The title compound is prepared from 2-bromo-5-iodo-1,3-dimethylbenzene and 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole following a procedure analogous to that described in Step 1 of Intermediate 17. LC (method 9): tR=1.11 min; Mass spectrum (ESI+): m/z=265 [M+H]+.
出典と根拠
- ORDレコード
- ord-c9382651a30f4963b846a6ce59ef1f31
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642585B2
反応ノート
読み込み中…