Triethylamine → 3-(trifluoromethyl)-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide

関与物質

反応手順

In a similar manner as described for Intermediate 10, 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine (Intermediate 9) (0.085 g, 0.28 mmol), triethylamine (0.10 mL, 0.72 mmol) and 3-(trifluoromethyl)-benzoyl chloride (0.065 g, 0.31 mmol) in dichloromethane (5 mL) gave 3-(trifluoromethyl)-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (0.12 g) as a yellow oil. MS m/z 478 (M+1).

情報源と証拠