Ammonium → 3-{5-Methyl-2-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-7-yl}benzamide
反応式
[CH3:1][C:2]1[N:3]=[C:4]([C:24]2[CH:25]=[C:26]([CH:31]=[CH:32][CH:33]=2)[C:27]([O:29]C)=O)[N:5]2[C:10]=1[CH:9]=[N:8][C:7]([NH:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[C:15]([O:20][CH3:21])=[C:14]([O:22][CH3:23])[CH:13]=1)=[N:6]2.[NH4+:34]>CO>[CH3:1][C:2]1[N:3]=[C:4]([C:24]2[CH:25]=[C:26]([CH:31]=[CH:32][CH:33]=2)[C:27]([NH2:34])=[O:29])[N:5]2[C:10]=1[CH:9]=[N:8][C:7]([NH:11][C:12]1[CH:13]=[C:14]([O:22][CH3:23])[C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1)=[N:6]2参加物
4
実験手順
To methyl 3-{5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-7-yl}benzoate (Example 12) (0.020 g, 0.044 mmol) was added 7N ammonium in methanol (5 mL). The solution was heated in a sealed tube for 18 hours. After cooling to room temperature, the volatiles were removed under reduced pressure to give 3-{5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-7-yl}benzamide (0.015 g) as a yellow solid. 1H NMR (CDCl3): δ9.41 (s, 1H), 9.16 (s, 1H), 8.73 (d, J=7.3 Hz, 1H), 8.27 (d, J=7.6 Hz, 1H), 8.23-8.17 (m, 1H), 7.75-7.59 (m, 3H) 7.26 (s, 2H), 3.98 (s, 3H), 3.92 (s, 3H), 3.72 (s, 3H), 2.71 (s, 3H). MS m/z 435 (M+1).