Water → 2-Bromo-5-((R)-3-methanesulfonyl-2-methyl-propoxy)-1,3-dimethyl-benzene

反応式

[Br:1][C:2]1[C:17]([CH3:18])=[CH:16][C:5]([O:6][CH2:7][C@@H:8]([CH3:15])[CH2:9]OS(C)(=O)=O)=[CH:4][C:3]=1[CH3:19].[CH3:20][S:21]([O-:23])=[O:22].[Na+].O>CN(C)C=O>[Br:1][C:2]1[C:3]([CH3:19])=[CH:4][C:5]([O:6][CH2:7][C@@H:8]([CH3:15])[CH2:9][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:16][C:17]=1[CH3:18]

参加物

実験手順

Methanesulfonic acid (R)-3-(4-bromo-3,5-dimethyl-phenoxy)-2-methyl-propyl ester (148 mg) and sodium methanesulfinate (215 mg) are stirred in 3 mL of N,N-dimethylformamide at 80° C. for 4 h. The reaction mixture is cooled to room temperature, water is added and the reaction mixture is extracted with diethyl ether. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give the title compound. Yield: 118 mg.