4-(4-Nitrophenyl)oxazole → 4-(Oxazol-4-yl)aniline

HRID 2375444ノート

反応式

HRID 2375444 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>[C].[Pd].C(O)C.O1CCCC1>[O:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[N:11]=[CH:12]1

参加物

5

反応物 2

HCID 145677974-(4-Nitrophenyl)oxazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 223978534-(Oxazol-4-yl)aniline

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 21873804Tetrahydrofuran ethanol溶媒

実験手順

5% Palladium-carbon powder was added to an ethanol-tetrahydrofuran mixed suspension of 4-(4-nitrophenyl)-1,3-oxazol and stirred for 12 hours at room temperature in a hydrogen atmosphere. The reaction solution was filtered through Celite and the filtrate was evaporated under reduced pressure. The resulting crude product is purified with a silica gel column chromatography to obtain [4-(1,3-oxazol-4-yl)phenyl]amine (pale yellow solid). Electron Impact-MS(M)+: 160.

後処理

  1. additionmixed
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe filtrate was evaporated under reduced pressure
  4. customThe resulting crude product is purified with a silica gel column chromatography

出典と根拠

ORDレコード
ord-1519ff411b454708a102c24fe406bc08
出典データセット
uspto-grants-2008_12
特許番号
US07465748B2

反応ノート

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