1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → HCID 21101317、化合物

HRID 2375471ノート

反応式

HRID 2375471 の反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]=1.[F:15][C:16]([F:30])([F:29])[C:17]1[C:18]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:19][CH:20]=[CH:21][CH:22]=1>ClC1C=CC=CC=1>[Cl:8][C:6]1[CH:5]=[C:4]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]=[C:2]([N:26]2[CH2:27][CH2:28][N:23]([C:18]3[C:17]([C:16]([F:30])([F:15])[F:29])=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:24][CH2:25]2)[N:7]=1

参加物

4

反応物 2

HCID 27777861-[3-(Trifluoromethyl)pyridin-2-yl]piperazineHCID 211012992,4-Dichloro-6-(piperidin-1-yl)pyrimidine

生成物 1

HCID 21101317HCID 21101317、化合物

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

反応条件

温度
140 °C

実験手順

A mixture of 2,4-dichloro-6-(1-piperidinyl)pyrimidine (100 mg, 0.43 mmol) and 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine (119 mg, 0.52 mmol) in chlorobenzene (1 mL) was heated at 140° C. in a sealed tube for 24 hours. The solvent was removed and the crude material was purified by preparative TLC, eluting with hexane/ethyl acetate (9:1). 4-chloro-6-(1-piperidinyl)-2-{4-[3-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl}pyrimidine was obtained as a solid (79 mg, 0.19 mmol, 44%).

後処理

  1. customThe solvent was removed
  2. customthe crude material was purified by preparative TLC
  3. washeluting with hexane/ethyl acetate (9:1)

出典と根拠

ORDレコード
ord-75ab530f064f4006944f51bbbe20681a
出典データセット
uspto-grants-2008_12
特許番号
US07465750B2

反応ノート

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