関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | 2(1H-indol-3-yl)ethylacetyltryptamineacetamide | HCID 86587735 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-Ethyltryptamine | HCID 6092 | 185.2% |
反応手順
Lithium aluminum hydride in tetrahydrofuran (1M, 30 mL) was added dropwise to a stirring solution of N-[2-(1H-indol-3-yl)ethylacetyltryptamineacetamide (2.02 g) in tetrahydrofuran (10 mL) at 0° C. The solution was then heated at reflux overnight. The solution was cooled to 0° C. and water was very carefully added dropwise. The white solid was filtered and rinsed with ether/methanol (9:1, 2×25 mL). The solvent was removed from the filtrate, giving N-ethyl-2-(1H-indol-3-yl)ethanamine as a viscous-pale yellow oil (1.75 g, 93%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07465750B2 |
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| 出典データセット | uspto-grants-2008_12 |
|---|
| ORD ID | ord-37368a20d5064cdba032289dbebd62d5 |
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| 出典メモ | uspto-grants-2008_12 |
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