Ethanol → (-)-Salbutamol

HRID 2375771

反応式

HRID 2375771 の反応式
[CH3:1][C:2]([NH:5][CH2:6][C@H:7]([OH:17])[C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:14][OH:15])[CH:13]=1)([CH3:4])[CH3:3].Cl.C(O)C>CC(OC)(C)C>[CH3:4][C:2]([NH:5][CH2:6][C@H:7]([OH:17])[C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:14][OH:15])[CH:13]=1)([CH3:1])[CH3:3]

参加物

4

反応物 2

HCID 702EthanolHCID 123601Levalbuterol Hydrochloride

生成物 1

HCID 123600(-)-Salbutamol

試薬・触媒・溶媒 1

HCID 15413tert-Butyl methyl ether溶媒

実験手順

In a 25 ml reactor equipped with a condenser, thermometer, and mechanical stirrer loaded at room temperature levalbuterol HCl (1.2 g) and absolute ethanol (15 ml). The solution was warmed to 45° C. to 50° to obtain a solution. The solution was cooled to room temperature and after MTBE (8.75 ml) was added. The solution was stirred at 15° C. for 2 hours to obtain a suspension. The solid was collected by filtration and washed with MTBE (3 ml) to obtain levalbuterol Polymorph A (0.8 g).

後処理

  1. customIn a 25 ml reactor equipped with a condenser
  2. customthermometer, and mechanical stirrer loaded at room temperature
  3. temperatureThe solution was warmed to 45° C. to 50°
  4. customto obtain a solution
  5. customto obtain a suspension
  6. filtrationThe solid was collected by filtration
  7. washwashed with MTBE (3 ml)

出典と根拠

ORDレコード
ord-c1e6a544fbba4ba4a713cd31a9877d59
出典データセット
uspto-grants-2008_12
特許番号
US07465831B2

関連ノート

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