(5-Chloropyrazin-2-yl)methanol → Ethyl (2E)-3-(5-chloro-2-pyrazinyl)acrylate
反応式
[Cl:1][C:2]1[N:3]=[CH:4][C:5]([CH2:8]O)=[N:6][CH:7]=1.[C:10]([CH:15]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:12][CH2:13][CH3:14])=[O:11].O1CCOCC1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5](/[CH:8]=[CH:15]/[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[N:6][CH:7]=1参加物
3
実験手順
To a solution of (5-chloro-2-pyrazinyl)methanol (11.0 g) in dioxane (carbethoxymethylene)triphenylphosphorane (29.2 g). After stirring for 2 hours at room temperature, a resulting precipitate was filtered and the filtrate was evaporated in vacuo. The residue was purified by column chromatography on silica gel to give ethyl (2E)-3-(5-chloro-2-pyrazinyl)acrylate (11.0 g).
後処理
- filtrationa resulting precipitate was filtered
- customthe filtrate was evaporated in vacuo
- customThe residue was purified by column chromatography on silica gel
出典と根拠
- ORDレコード
- ord-f3ed3b931f244fbf9b59a346da780e91
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07465731B2
反応ノート
読み込み中…