3-Bromo-2-fluoropyridine → 3-((1S)-1-(tert-Butyldimethylsilyloxy)-7-fluoro-2,3-dihydro-1H-inden-4-yl)-2-fluoropyridine

HRID 237610ノート

反応式

HRID 237610 の反応式
[C:1]([Si:5]([O:8][C@@H:9]1[C:17]2[C:12](=[C:13](B3OC(C)(C)C(C)(C)O3)[CH:14]=[CH:15][C:16]=2[F:18])[CH2:11][CH2:10]1)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].Br[C:29]1[C:30]([F:35])=[N:31][CH:32]=[CH:33][CH:34]=1.BrC1C=CC(F)=C2C=1CC[C@H]2OC1C=CC2[C@H](CC(OC)=O)COC=2C=1>>[Si:5]([O:8][C@@H:9]1[C:17]2[C:12](=[C:13]([C:29]3[C:30]([F:35])=[N:31][CH:32]=[CH:33][CH:34]=3)[CH:14]=[CH:15][C:16]=2[F:18])[CH2:11][CH2:10]1)([C:1]([CH3:3])([CH3:4])[CH3:2])([CH3:6])[CH3:7]

参加物

4

反応物 3

HCID 27627783-Bromo-2-fluoropyridineHCID 86697103{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697282(S)-tert-butyl(7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)dimethylsilane

生成物 1

HCID 866972813-((1S)-1-(tert-Butyldimethylsilyloxy)-7-fluoro-2,3-dihydro-1H-inden-4-yl)-2-fluoropyridine

実験手順

The title compound is prepared from (S)-tert-butyl(7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)dimethylsilane and 3-bromo-2-fluoropyridine following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 7): tR=1.31 min.; Mass spectrum (ESI+): m/z=362 [M+H]+.

出典と根拠

ORDレコード
ord-4b2e2ad181de49d2acc4f04aa52b4166
出典データセット
uspto-grants-2014_02
特許番号
US08642585B2

反応ノート

読み込み中…