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2-Bromobenzenesulfonyl chloride → N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-bromobenzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromobenzenesulfonyl chloride | HCID 520403 | — |
| 反応物 | 3-Methoxy-5-methyl-2-pyrazinamine | HCID 10701894 | — |
| 生成物 | N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-bromobenzenesulfonamide | HCID 22574647 | — |
反応手順
2-amino-3-methoxy-5-methylpyrazine (1.50 g, 10.8 mmol; synthesized according to Bradbury, R. H., et. al. J. Med. Chem. 1997, 40, 996-1004) and 2-bromobenzenesulfonyl chloride (2.80 g, 11.0 mmol) were reacted according to the procedure of Example 25, Step A. 44A was a pink solid, 2.0 g (52%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06852745B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-32684a7f2dc54df6a229f66d61bb8a06 |
| 出典メモ | uspto-grants-2005_02 |