2-Methylpyridine-4-boronic acid pinacol ester → 4-(4-Bromo-3,5-dimethyl-phenyl)-2-methyl-pyridine

反応式

[CH3:1][C:2]1[CH:7]=[C:6](B2OC(C)(C)C(C)(C)O2)[CH:5]=[CH:4][N:3]=1.[Br:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21](I)=[CH:20][C:19]=1[CH3:26]>>[Br:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=2)=[CH:20][C:19]=1[CH3:26]

参加物

反応物 2

HCID 164142742-Methylpyridine-4-boronic acid pinacol ester

HCID 207480372-Bromo-5-iodo-1,3-dimethylbenzene

生成物 1

HCID 866972944-(4-Bromo-3,5-dimethyl-phenyl)-2-methyl-pyridine

実験手順

The title compound is prepared from 2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine and 2-bromo-5-iodo-1,3-dimethyl-benzene following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 9): tR=0.87 min; Mass spectrum (ESI+): m/z=276/278 (Br) [M+H]+.

出典と根拠

ORDレコード: ord-08a9d603858d48438b97ec8eea88e213
出典データセット: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08642585B2

反応ノート

読み込み中…

参加物