4-Bromo-2,6-dimethylpyrimidine → 4-(4-Bromo-3,5-dimethyl-phenyl)-2,6-dimethyl-pyrimidine
反応式
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Br[C:20]1[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([CH3:27])[N:21]=1>>[Br:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([CH3:27])[N:21]=2)=[CH:6][C:7]=1[CH3:8]参加物
3
実験手順
The title compound is prepared from 2-bromo-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 4-bromo-2,6-dimethyl-pyrimidine following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 7): tR=1.01 min; Mass spectrum (ESI+): m/z=291/293 (Br) [M+H]+.
出典と根拠
- ORDレコード
- ord-c77bf69497f8481e8bc26f3ce54c1ded
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642585B2
反応ノート
読み込み中…