2-Methylpyridine-5-boronic acid → 5-(4-Bromo-3,5-dimethyl-phenyl)-2-methyl-pyridine

反応式

[CH3:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][N:3]=1.[Br:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15](I)=[CH:14][C:13]=1[CH3:20]>>[Br:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[N:3][CH:4]=2)=[CH:14][C:13]=1[CH3:20]

参加物

反応物 2

HCID 27630812-Methylpyridine-5-boronic acid

HCID 207480372-Bromo-5-iodo-1,3-dimethylbenzene

生成物 1

HCID 866973115-(4-Bromo-3,5-dimethyl-phenyl)-2-methyl-pyridine

実験手順

The title compound is prepared from 2-methyl-pyridine-5-boronic acid and 2-bromo-5-iodo-1,3-dimethyl-benzene following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 9): tR=0.93 min; Mass spectrum (ESI+): m/z=276/278 (Br) [M+H]+.

出典と根拠

ORDレコード: ord-f3ef43ef2dca4acd8ad53bdc9f523824
出典データセット: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08642585B2

反応ノート

読み込み中…