3-Chloro-5-methoxypyridazine → 3-(4-Chloro-3,5-dimethyl-phenyl)-5-methoxy-pyridazine
反応式
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Cl[C:20]1[N:21]=[N:22][CH:23]=[C:24]([O:26][CH3:27])[CH:25]=1>>[Cl:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[N:21]=[N:22][CH:23]=[C:24]([O:26][CH3:27])[CH:25]=2)=[CH:6][C:7]=1[CH3:8]参加物
3
実験手順
The title compound is prepared from 2-chloro-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 3-chloro-5-methoxy-pyridazine following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 11): tR=0.93 min; Mass spectrum (ESI+): m/z=249/251 (Cl) [M+H]+.
出典と根拠
- ORDレコード
- ord-5449faba2fb54a708a93a6ab648ed7b1
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08642585B2
反応ノート
読み込み中…