Morpholine → HCID 58855409、化合物

反応式

[F:1][C:2]([F:18])([C:9]([F:17])([F:16])[C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])[CH2:3][O:4][CH2:5][CH:6]1[O:8][CH2:7]1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[O:22]1[CH2:23][CH2:24][N:19]([CH2:7][CH:6]([OH:8])[CH2:5][O:4][CH2:3][C:2]([F:18])([F:1])[C:9]([F:17])([F:16])[C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])[CH2:20][CH2:21]1

参加物

反応物 2

HCID 8083Morpholine

HCID 27758863-(1h,1h,5h-Octafluoropentyloxy)-1,2-epoxypropane

生成物 1

HCID 58855409HCID 58855409、化合物収率 89.1%

反応条件

温度: 80 °C

実験手順

28.8 g of glycidyl 2,2,3,3,4,4,5,5-octafluoropentyl ether was added dropwise to 8.7 g of morpholine. The mixture was then stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography. There was obtained 33.4 g of 1-morpholino-3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-2-propanol (yield 89%).

後処理

customThe reaction mixture was directly purified by silica gel column chromatography

出典と根拠

ORDレコード: ord-2486bcc7ee5744469b72e13b206d08ae
出典データセット: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07468236B2

反応ノート

読み込み中…