Piperidin-4-ol → 1-[2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]ethyl]piperidin-4-ol

HRID 2376755ノート

反応式

HRID 2376755 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[C:10](=[N:27][N:28]([CH2:30][CH:31]=O)[CH:29]=3)[N:11]=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[C:13]=2[C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[OH:47][CH:48]1[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]1>ClCCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[C:10](=[N:27][N:28]([CH2:30][CH2:31][N:51]4[CH2:52][CH2:53][CH:48]([OH:47])[CH2:49][CH2:50]4)[CH:29]=3)[N:11]=[C:12]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[C:13]=2[C:14]2[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 79341Piperidin-4-olHCID 5049666Sodium triacetoxyborohydrideHCID 86606798HCID 86606798、化合物

生成物 1

HCID 684448031-[2-[4,6-Bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]ethyl]piperidin-4-ol収率 20%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

In a volumetric flask, 2-[4,6-bis(4-fluorophenyl)-5-(4-pyridyl)pyrazolo[3,4-b]pyridin-2-yl]acetaldehyde (0.08 g, 0.2 mmol, obtained in example 94), sodium triacetoxyborohydride (0.08 g, 0.4 mmol), 4-hydroxypiperidine (0.02 g, 0.2 mmol) and 1,2-dichloroethane (3 mL) were introduced under argon atmosphere. The mixture was stirred overnight at room temperature. It was concentrated and a mixture of water and EtOAc were added. The phases were separated. The aqueous phase was extracted with EtOAc. The organic phase was dried over Na2SO4 and concentrated to dryness. The crude product obtained was purified by chromatography on silica gel using increasing polarity mixtures of EtOAc-MeOH as eluent, to afford 19 mg of the title compound (yield: 20%).

後処理

  1. concentrationIt was concentrated
  2. additiona mixture of water and EtOAc
  3. additionwere added
  4. customThe phases were separated
  5. extractionThe aqueous phase was extracted with EtOAc
  6. dry with materialThe organic phase was dried over Na2SO4
  7. concentrationconcentrated to dryness
  8. customThe crude product obtained
  9. customwas purified by chromatography on silica gel using
  10. temperatureincreasing polarity mixtures of EtOAc-MeOH as eluent

出典と根拠

ORDレコード
ord-751a0f4427c44917ab193469f1dd594e
出典データセット
uspto-grants-2008_12
特許番号
US07468376B2

反応ノート

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