2-Bromo-5-methylpyridine → 2-(4-Chloro-3,5-dimethyl-phenyl)-5-methyl-pyridine

HRID 237683ノート

反応式

HRID 237683 の反応式
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Br[C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][N:21]=1>>[Cl:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][N:21]=2)=[CH:6][C:7]=1[CH3:8]

参加物

3

反応物 2

HCID 5642162-Bromo-5-methylpyridineHCID 532171282-(4-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

生成物 1

HCID 866973572-(4-Chloro-3,5-dimethyl-phenyl)-5-methyl-pyridine

実験手順

The title compound is prepared from 2-chloro-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 2-bromo-5-methyl-pyridine following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 7): tR=0.90 min; Mass spectrum (ESI+): m/z=232/234 (Cl) [M+H]+.

出典と根拠

ORDレコード
ord-e13b9e5a9a1f4e019c2f41e96d825a0d
出典データセット
uspto-grants-2014_02
特許番号
US08642585B2

反応ノート

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