関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Acrylonitrile | HCID 7855 | — |
| 反応物 | Sodium 4-bromobenzene-1-sulfinate--water (1/1/2) | HCID 23683129 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-((4-Bromophenyl)sulfonyl)propanenitrile | HCID 2049781 | 86% |
反応手順
To a suspension of sodium 4-bromophenylsulfinate dihydrate (130 g, 0.53 mol) in water (600 mL) was added acrylonitrile (70 mL, 1.07 mol) and acetic acid (62 mL, 1.07 mol). The reaction was stirred for 1.5 h at 100° C. then cooled to room temperature. The solid was filtered off, washed thoroughly with water and dried over P2O5 to give 3-[(4-bromophenyl)sulfonyl]propanenitrile (125 g). δH (400, CDCl3): 7.27-7.22 (4H, m), 2.85 (2H, t, J 7.6), 2.30 (2H, t, J 7.6).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07468393B2 |
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| 出典データセット | uspto-grants-2008_12 |
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| ORD ID | ord-82425e37651b4b07ae1c536efa25a17a |
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| 出典メモ | uspto-grants-2008_12 |
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