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Methyl 2-bromobenzoate → Methyl 2-[(4-bromophenyl)sulfonyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2-bromobenzoate | HCID 11894 | — |
| 反応物 | Sodium 4-bromobenzene-1-sulfinate--water (1/1/2) | HCID 23683129 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | Methyl 2-[(4-bromophenyl)sulfonyl]benzoate | HCID 21099525 | — |
反応手順
Methyl 2-[(4-bromophenyl)sulfonyl]benzoate was prepared according to the method of Example 135, Step 2 using methyl 2-bromobenzoate (2.8 mL, 20 mmol) in place of (S)-1-(2-iodophenyl)ethanol and sodium 4-bromophenylsulfinate dihydrate (5.6 g, 20 mmol) in place of Intermediate 1, together with CuI (19 g, 100 mmol) and DMSO (40 mL), affording product as a white solid (3.8 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07468393B2 |
| 出典データセット | uspto-grants-2008_12 |
| ORD ID | ord-b78c719f709948d286aa5bc8f3621bc0 |
| 出典メモ | uspto-grants-2008_12 |