Dimethylformamide dimethyl acetal → HCID 86602114、化合物

HRID 2377047ノート

反応式

HRID 2377047 の反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1.CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>CN(C=O)C>[CH3:18][N:19]([CH3:21])/[CH:20]=[CH:1]/[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:3]=1

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 44549262HCID 44549262、化合物

生成物 1

HCID 86602114HCID 86602114、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

A mixture of ethyl 4-methyl-5-nitropyridine-2-carboxylate (39.5 g, 0.19 mol), dimethylformamide-dimethylacetal (DMF-DMA) (30.6 g, 0.26 mol, 1.35 eq) in DMF (470 mL) was heated to 90° C. for 30 min. The solvent was removed in vacuo. The residue (78 g) was used without further purification in the next step.

後処理

  1. customThe solvent was removed in vacuo
  2. customThe residue (78 g) was used without further purification in the next step

出典と根拠

ORDレコード
ord-b4dc6674623440ea8dd4409b12dd4645
出典データセット
uspto-grants-2008_12
特許番号
US07468375B2

反応ノート

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