4-Fluoro-2-hydroxyphenacyl bromide → 6-Fluoro-2,3-dihydro-1-benzofuran-3-one
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[OH:12])=[O:4]>CN(C=O)C.O>[F:11][C:8]1[CH:9]=[CH:10][C:5]2[C:3](=[O:4])[CH2:2][O:12][C:6]=2[CH:7]=1参加物
4
実験手順
CsCO3 (5.36 g) was added in portions over 10 min to an ice cold solution of Example 1109A (3.2 g) in DMF (140 mL). The resulting mixture was stirred for 30 min then diluted with water and extracted with ether (3×). the combined extracts were dried (Na2SO4), and concentrated to give 1.6 g of the title compound. MS ESI(−) m/e 151.1 (M−H)−.
後処理
- extractionextracted with ether (3×)
- dry with materialthe combined extracts were dried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5017a460639f48b887a99440acc67f77
- 出典データセット
- uspto-grants-2008_12
- 特許番号
- US07468371B2
反応ノート
読み込み中…