Potassium Carbonate → HCID 57424255、化合物

HRID 2377443ノート

反応式

HRID 2377443 の反応式
[CH:1]([O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][C:7]=1[CH2:18][N:19]([CH:21]1[CH2:23][CH2:22]1)[CH3:20])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]([O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[CH:13])=[CH:8][C:7]=1[CH2:18][N:19]([CH:21]1[CH2:23][CH2:22]1)[CH3:20])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 69076270HCID 69076270、化合物2 回

生成物 1

HCID 57424255HCID 57424255、化合物収率 78%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution 2-[(cyclopropyl-methyl-amino)-methyl]-4-trimethylsilanylethynyl-benzoic acid isopropyl ester (Intermediate 121, 0.34 g, 1 mmol) in methanol (2 mL) was treated with potassium carbonate (0.207 g, 1.5 mmol) and the resulting reaction mixture was stirred at ambient temperature for 4 h. The volatiles were evaporated in vacuo, the residue was diluted with water and extracted with diethyl ether, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as an oil (0.21 g, 78%).

後処理

  1. customthe resulting reaction mixture
  2. customThe volatiles were evaporated in vacuo
  3. additionthe residue was diluted with water
  4. extractionextracted with diethyl ether
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-dcc4ef60c121401ca7749a5d76e03985
出典データセット
uspto-grants-2008_12
特許番号
US07468391B2

反応ノート

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