2-Methylaziridine → 2-Methyl-1-Tosyl-Aziridine

HRID 23775

反応式

HRID 23775 の反応式
[CH3:1][CH:2]1[CH2:4][NH:3]1.[C:5]1([CH3:15])[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1>[OH-].[K+]>[CH3:1][CH:2]1[CH2:4][N:3]1[S:11]([C:8]1[CH:9]=[CH:10][C:5]([CH3:15])=[CH:6][CH:7]=1)(=[O:13])=[O:12]

参加物

4

反応物 2

HCID 63772-MethylaziridineHCID 73974-Toluenesulfonyl chloride

生成物 1

HCID 5448752-Methyl-1-Tosyl-Aziridine収率 58.5%

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

反応条件

温度
0 °C

実験手順

2-Methylaziridine (3.6 ml, 51 mmol) was added to a 10% aqueous KOH solution (30 ml) and cooled in an ice bath for 30 min. To this solution p-toluenesulfonyl chloride (9.9 g, 52 mmol) was added rapidly while maintaining the temperature below 4° C. The resulting mixture was stirred for 30 min at 0° C., then stirred at room temperature overnight. The white precipitate was washed multiple times with cold water and dried under vacuum. The washed product was dissolved in hot petroleum ether and allowed to crystallize at 0° C., yielding colorless crystals (6.3 g, 57% yield).

後処理

  1. temperaturecooled in an ice bath for 30 min
  2. temperaturewhile maintaining the temperature below 4° C
  3. stirringstirred at room temperature overnight
  4. washThe white precipitate was washed multiple times with cold water
  5. customdried under vacuum
  6. dissolutionThe washed product was dissolved in hot petroleum ether
  7. customto crystallize at 0° C.

出典と根拠

ORDレコード
ord-cf0ac7519533440aacba03633ef402c8
出典データセット
uspto-grants-2005_02
特許番号
US06852865B2

関連ノート

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