1-(4-Benzyloxy-phenyl)-3,3-dimethyl-cyclohexanol → 1-Benzyloxy-4-(3,3-dimethyl-cyclohex-1-enyl)-benzene

HRID 237759ノート

反応式

HRID 237759 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2(O)[CH2:20][CH2:19][CH2:18][C:17]([CH3:22])([CH3:21])[CH2:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCO.Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH2:20][CH2:19][CH2:18][C:17]([CH3:22])([CH3:21])[CH:16]=2)=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 685239591-(4-Benzyloxy-phenyl)-3,3-dimethyl-cyclohexanol

生成物 1

HCID 685247081-Benzyloxy-4-(3,3-dimethyl-cyclohex-1-enyl)-benzene収率 92.4%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

1-(4-Benzyloxy-phenyl)-3,3-dimethyl-cyclohexanol (5.08 g, 16.4 mmol) was dissolved in EtOH (80 mL) after which concentrated hydrochloric acid (8 mL) was added. This mixture was stirred at 50° C. for 1.5 hours. The solvent was removed under reduced pressure. Water (15 mL) was added. The mixture was basified with aqueous ammonia and extracted three times with EtOAc. The organic phase was dried and concentrated to provide the title compound as a yellow solid 4.43 g as a mixture of isomers.

後処理

  1. additionwas added
  2. customThe solvent was removed under reduced pressure
  3. additionWater (15 mL) was added
  4. extractionextracted three times with EtOAc
  5. customThe organic phase was dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-0abd5aa8aad74627a470f8b01f77990a
出典データセット
uspto-grants-2014_02
特許番号
US08642603B2

反応ノート

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