5-Hexenoyl chloride → N-[(Hex-5-en-1-yl)(methyl)carbamoyl]-3-methyl-L-valine

反応式

[CH3:1][C:2]([CH3:18])([CH3:17])[C@@H:3]([C:14]([OH:16])=[O:15])[NH:4][C:5]([N:7]([CH3:13])[CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12])=[O:6].[C:19](Cl)(=O)CCCC=C>>[CH3:1][C:2]([CH3:18])([CH3:17])[C@@H:3]([C:14]([OH:16])=[O:15])[NH:4][C:5]([N:7]([CH3:13])[CH2:8][CH2:9][CH2:10][CH2:11][CH:12]=[CH2:19])=[O:6]

参加物

反応物 2

HCID 109755195-Hexenoyl chloride

HCID 574311913-Methyl-N-[methyl(pent-4-en-1-yl)carbamoyl]-L-valine

生成物 1

HCID 57431192N-[(Hex-5-en-1-yl)(methyl)carbamoyl]-3-methyl-L-valine

実験手順

3-Methyl-N-{[methyl(hex-5-enyl)amino]carbonyl}-L-valine was prepared according to the procedure for 3-methyl-N-{[methyl(pent-4-enyl)amino]carbonyl}-L-valine (Steps 1-5) by using 5-hexenoyl chloride instead of 4-pentenoyl chloride in Step 1. LRMS (ESI) m/z 271 [(M+H)+; calcd for C14H27N2O3: 271].

出典と根拠

ORDレコード: ord-1ad30dff3fab40ff956ae072b8b8448e
出典データセット: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07470664B2

反応ノート

読み込み中…

参加物