9-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonan-9-ol → 9-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonane

HRID 237763ノート

反応式

HRID 237763 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2(O)[CH:20]3[CH2:21][CH2:22][CH2:23][CH:16]2[CH2:17][CH2:18][CH2:19]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCO.Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]2[CH:20]3[CH2:21][CH2:22][CH2:23][CH:16]2[CH2:17][CH2:18][CH2:19]3)=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 670610079-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonan-9-ol

生成物 1

HCID 685293519-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonane収率 123.2%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

9-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonan-9-ol (4.7 g, 14.57 mmol) (prepared in accordance with the procedures set forth in Step 2 of Example 18) was dissolved in EtOH (150 mL) after which concentrated hydrochloric acid (15 mL) was added. This mixture was stirred at 50° C. overnight. The solvent was removed under reduced pressure. Water (50 mL) was added. The mixture was basified with aqueous ammonia and extracted three times with EtOAc. The organic phase was dried and concentrated to provide the title compound (5.5 g).

後処理

  1. additionwas added
  2. customThe solvent was removed under reduced pressure
  3. additionWater (50 mL) was added
  4. extractionextracted three times with EtOAc
  5. customThe organic phase was dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-73011340c21b43668ee6c3df638197a1
出典データセット
uspto-grants-2014_02
特許番号
US08642603B2

反応ノート

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