Methanol → 2-(4-Fluorophenylamino)but-2-enedioic Acid Dimethyl Ester

反応式

[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9]([C:14]([O:16][CH3:17])=[O:15])#[C:10][C:11]([O-:13])=[O:12].[CH3:18]O>>[CH3:17][O:16][C:14](=[O:15])[C:9]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=1)=[CH:10][C:11]([O:13][CH3:18])=[O:12]

参加物

反応物 3

HCID 887Methanol

HCID 97314-Fluoroaniline

HCID 86613298Methyl acetylene-dicarboxylate

生成物 1

HCID 691174942-(4-Fluorophenylamino)but-2-enedioic Acid Dimethyl Ester

反応条件

温度: 55 °C

実験手順

50 ml (0.51 M) of 4-fluoroaniline (at 98%) are introduced into 500 ml of anhydrous methanol, followed by dropwise addition of 70.5 ml (0.56 M) of methyl acetylenedicarboxylate (at 98%). The reaction mixture is heated at 55° C. with stirring for 3 hours, and then evaporated under reduced pressure. The residue is purified by evolution through silica.