2-Propynoic acid, 3-phenyl-, ethyl ester → (S)-2-(4-Cyclohexyl-phenoxymethyl)-5-phenyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

HRID 237813

反応式

HRID 237813 の反応式
[CH:1]1([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@H:13]3[O:17][C:16]([NH2:18])=[N:15][CH2:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:21]1([C:27]#[C:28][C:29](OCC)=[O:30])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CS(C)=O>[CH:1]1([C:7]2[CH:20]=[CH:19][C:10]([O:11][CH2:12][C@H:13]3[O:17][C:16]4=[N:18][C:29](=[O:30])[CH:28]=[C:27]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=5)[N:15]4[CH2:14]3)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 915162-Propynoic acid, 3-phenyl-, ethyl esterHCID 66875140(S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine

生成物 1

HCID 59252505(S)-2-(4-Cyclohexyl-phenoxymethyl)-5-phenyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The title compound was prepared from (S)-5-(4-cyclohexyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and ethyl phenylpropiolate employing the procedure described in Example 76. [α]D25 +100.26 (c 0.507, DMSO).

出典と根拠

ORDレコード
ord-7047615d5b934326a83259fe56822e95
出典データセット
uspto-grants-2014_02
特許番号
US08642603B2

関連ノート

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