(+)-Benzyl glycidyl ether → HCID 68527184、化合物

HRID 237879ノート

反応式

HRID 237879 の反応式
[N:1]#[C:2][NH2:3].[Na].[CH2:5]([O:12][CH2:13][C@@H:14]1[CH2:16][O:15]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CO>[CH2:5]([O:12][CH2:13][C@H:14]1[O:15][C:2]([NH2:3])=[N:1][CH2:16]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 146296(+)-Benzyl glycidyl etherHCID 57375518Cyanamidnatrium

生成物 1

HCID 68527184HCID 68527184、化合物収率 96%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a vigorously stirred solution of sodium hydrogen cyanamide (1.95 g, 30.4 mmol) in methanol (30.5 mL) was added dropwise (S)-2-benzyloxymethyl-oxirane (5 g, 30.4 mmol) in methanol. The reaction mixture was stirred at room temperature overnight after which the reaction mixture was concentrated to remove methanol. Ethyl acetate was added (150 mL) along with 50 ml of water. The contents were transferred to a separatory funnel, the organic layer was removed, dried over Na2SO4 and concentrated under vacuum to give 6.01 g (96%) of the title compound.

後処理

  1. concentrationwas concentrated
  2. customto remove methanol
  3. additionEthyl acetate was added (150 mL) along with 50 ml of water
  4. customThe contents were transferred to a separatory funnel
  5. customthe organic layer was removed
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-babb6067cdf046538ca41461844b2546
出典データセット
uspto-grants-2014_02
特許番号
US08642603B2

反応ノート

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