Hydrogen Peroxide → HCID 15766288、化合物
反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]([NH2:11])=[O:10].[OH:14]O>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[CH:8]=[CH:7][N+:6]([O-:14])=[CH:5][C:4]=1[C:9]([NH2:11])=[O:10]参加物
4
反応条件
- 温度
- 70 °C
実験手順
0.8 g of 4-trifluoromethyl-3-pyridine carboxamide was dissolved in 7 ml of acetic acid. Then, 0.72 g of a 30% hydrogen peroxide aqueous solution was gradually dropwise added thereto. After completion of the dropwise addition, the reaction solution was heated to 70° C. and stirred for 8 hours at this temperature. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue thereby obtained was washed with n-hexane to obtain 0.6 g of 4-trifluoromethyl-3-pyridine carboxamide 1-oxide (melting point: 198.8° C.) as the desired product.
後処理
- additionAfter completion of the dropwise addition
- customAfter completion of the reaction
- distillationthe solvent was distilled off under reduced pressure
- customThe residue thereby obtained
- washwas washed with n-hexane
出典と根拠
- ORDレコード
- ord-9ef1bc7d7c344a3a991d240e3d1e40ed
- 出典データセット
- uspto-grants-1994_11
- 特許番号
- US05360806
反応ノート
読み込み中…